HEPES Biotech, GMP, LBLE

GMP Biotech Product

HEPES BIOTECH

LBLE*, GMP
Product Code: HEPE-4250

*Low Bioburden, Low Endotoxin

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Product Code: HEPE-4250

Suitable for use in biological and biotech chemical process applications from R&D through scale cGMP production.

HEPES, Free Acid is a zwitterionic buffer used to maintain pH of media used in cell cultures. It is one of Good’s buffers that has a pKa value similar to its pH value, making it an ideal buffer for pH maintenance. HEPES is a Good’s buffer because it has low UV absorptivity, minimal reactivity, stable pH and is soluble in water.

Formula: C₈H₁₈N₂O₄S
F.W.: 238.30 g/mol
CAS #: 7365-45-9

Product Specifications

ANALYSIS

SPECIFICATIONS

Absorbance (0.1M)

250 nm

260 nm

280 nm

< = 0.0500 a.u.

< = 0.0800 a.u.

Absorbance (0.5M)

250 nm

260 nm

280 nm

< = 0.0500 a.u.

< = 0.0800 a.u.

Appearance and Color

White Crystals

Assay, Dried Basis

> = 99.5%

Chloride

< = 50 ppm

Endotoxin

< = 5 EU/g

Enzymes

DNase

RNase

Protease

None Detected

Identification, IR

Conforms to Reference Standard

Insoluble Matter

< = 0.01%

Loss on Drying

< = 0.5%

Microbial Content

TAMC

TYMC

< = 100 CFU/g

pH (5%)

5.0 - 6.5

pKa

7.45 - 7.65

Residue on Ignition

< = 0.1%

Solubility

Solubility (5%)

Solubility (0.05M)

Passes Test

Sulfate

< = 50 ppm

Trace Metals

Arsenic (As)

Aluminum (Al)

Bismuth (Bi)

Calcium (Ca)

Copper (Cu)

Iron (Fe)

Lead (Pb)

Lithium (Li)

Molybdenum (Mo)

Nickel (Ni)

Potassium (K)

< = 5 ppm

< = 10 ppm

< = 5 ppm

< = 1 ppm

< = 5 ppm

< = 50 ppm

Water, KF

< = 0.1%

Printable Version

Key Product Features:

Appears as a white crystalline product
Manufactured in accordance with IPEC
Manufactured in an enzyme free, hormone free and animal free environment
Contains no known major food allergens (as defined by FDA and WHO)
The final product and its raw materials are not derived from nor come into contact with animals, animal parts, animal products, and/or animal byproducts or derivatives.
Is not subject to genetic modification
Synonyms: N-(2-Hydroxyethyl) Piperazine-N'-2-Ethanesulfonic Acid; 4-(2-Hydroxyethyl) Piperazine-1-Ethanesulfonic Acid

Shelf-Life Policy:

Unless otherwise noted on the Shelf-Life Statement and CoA, this product has a 2-year retest date supported by a 3-year ICH Q1 Stability Study (if one is completed).

Storage & Shipping:

Refer to SDS.

Package Sizes:

100g, 500g, 1kg, 5kg, 10kg, 25kg, 50kg

Bulk GMP Fine Chemicals exclusively manufactured in North America

American Manufactured - FDA Registered GMP Facilities: Parenteral Excipients, GMP Small Molecule Intermediates, GMP Biological Buffers, Parenteral Carbohydrates, GMP Chlorinated Amino Acids, GMP Solutions in Sterile Single Use Packaging and other Reagent & GMP Fine Chemicals.